Name | 3-oxolup-20(29)-en-28-oic acid |
Synonyms | LiquidaMba Betulonic acid betulonic acid Betunolic acid Betulinonic acid Liquidambaric acid Liquidambaric acid 4481-62-3 3-Oxolup-20(29)-en-28-oic acid 3-oxolup-20(29)-en-28-oic acid lup-20(29)-en-28-oic acid, 3-oxo- Lup-20(29)-en-28-oic acid, 3-oxo- |
CAS | 4481-62-3 |
InChI | InChI=1/C30H46O3/c1-18(2)19-10-15-30(25(32)33)17-16-28(6)20(24(19)30)8-9-22-27(5)13-12-23(31)26(3,4)21(27)11-14-29(22,28)7/h19-22,24H,1,8-17H2,2-7H3,(H,32,33)/t19-,20+,21-,22+,24+,27-,28+,29+,30-/m0/s1 |
Molecular Formula | C30H46O3 |
Molar Mass | 454.68 |
Density | 1.061±0.06 g/cm3(Predicted) |
Melting Point | 253 °C |
Boling Point | 548.1±33.0 °C(Predicted) |
Specific Rotation(α) | +31.5°(methanol) |
Flash Point | 299.4°C |
Solubility | Soluble in alkaline solvents. |
Vapor Presure | 1.83E-13mmHg at 25°C |
Appearance | White powdered crystal |
Color | White to Off-White |
pKa | 4.62±0.70(Predicted) |
Storage Condition | under inert gas (nitrogen or Argon) at 2-8°C |
Refractive Index | 1.527 |
MDL | MFCD08459607 |
Physical and Chemical Properties | Betulinic acid is white crystalline powder, is a kind of pentacyclic triterpenoid compounds widely distributed in many plants, the content of birch bark is 0.25~2%(dry). |
In vitro study | Betulonic acid (72 h) inhibits the growth of various types of human tumor cell lines, including MGC-803, PC3, Bcap-37, A375, MCF-7 tumor cell lines, with IC 50 s of 17.7, 13.9, 25.7, 28.9, 18.2 μM, respectively. Betulonic acid has antiplasmodial activity, with IC 50 of 10 μM. Betulonic acid inhibits HSV-1, ECHO6 and influenza FPV viruses, with EC 50 s of 0.9, 73.32, and 5.7 µM, respectively. |
Safety Description | 24/25 - Avoid contact with skin and eyes. |
HS Code | 29389090 |
Reference Show more | 1. [IF=4.411] Zewen Chu et al."Betulonic Acid, as One of the Active Components of the Celastrus orbiculatus Extract, Inhibits the Invasion and Metastasis of Gastric Cancer Cells by Mediating Cytoskeleton Rearrangement In Vitro."Molecules. 2022 Jan;27(3):1025 |
overview | betulinic acid has anti-tumor, anti-virus and anti-inflammatory biological activities, among which it is famous for anti-melanoma. In addition, betulinic acid can induce cancer cell apoptosis (apoptosis), inhibit tumor growth and resist angiogenesis, and has a selective toxic effect between normal cells and cancer cells, showing its potential in cancer treatment. |
biological activity | Betulonic acid (Betunolic acid) is a triterpenoid compound found in many plants. Betulonic acid has anti-tumor, anti-inflammatory, anti-parasitic and anti-viral (HSV-1) activities. |
Use | Studies have found that betulinic acid can induce cancer cell apoptosis (apoptosis), inhibit tumor growth and fight angiogenesis, and has a selective toxicity between normal cells and cancer cells, showing its potential in cancer treatment. In addition, betulinic acid also has a new mechanism in the fight against HIV, which makes betulinic acid a promising active drug. used for content determination/identification/pharmacological experiment, etc. Pharmacological effects: anti-inflammatory and analgesic effects. |